During this preclinical stage of Alzheimer’s disease, people seem to be symptom-free, however, toxic changes are taking place in the brain. Abnormal deposits of proteins form amyloid plaques and tau tangles during the brain, and once-healthy neurons prevent functioning and lose connections with other neurons and perish. Dementia is a broad word for a decline in mental ability severe enough to interfere with daily life. Memory loss is an example. Alzheimer’s is the most common type of dementia. About Dementia. Symptoms. Like all kinds of dementia, Alzheimer’s disease is due to brain cell death. It’s a neurodegenerative disease so that there was innovative brain cell death that occurs over a course of time. The whole brain size shrinks with Alzheimer’s - the tissues has progressively fewer nerve cells and relations. Age is the greatest risk factor for Alzheimer’s disease. The disease mainly affects people over 65. Above this era, an individual’s risk of developing Alzheimer’s disease doubles approximately every five years. One in six people over 80 have dementia.
L. James Lee, professor of Chemical and Biomolecular Engineering in Ohio State’s College of Engineering and Co Author of the study explained: “The concept is very simple. In my lab, we have ongoing research trying to understand the mechanism and do even better. The future of regenerative medicine only got improved with a ‘breakthrough’ technology which will enable damaged organs to regrow and acute wounds to heal faster. “The concept is very simple,” Lee stated. So, this is the beginning, more to come.”
TNT technology includes two major components: First can be a nanotechnology-based chip designed to deliver freight to mature cells from the live body. Second is the design of specific biological freight to cell conversion. This cargo, when delivered using the chip, converts an adult cell from 1 type into the other, said first author Daniel Gallego-Perez, an assistant professor of biomedical engineering and general operation who also was a postdoctoral researcher at the Sun’s and Lee’s laboratories. TNT doesn’t need any laboratory-based procedures and might be implemented at the point of care. The procedure is additionally non-toxic. The freight has been delivered by zapping these devices with a tiny electrical charge that’s barely felt by the patient.